Bead-free, enzyme-free rRNA depletion. >98% depletion efficiency, at less than half the price of other depletion kits.
Pre-configured catcher strands included, add your total RNA and run.
Ready-to-Use Kit
Need a custom DNA or RNA target instead? Try LASSOflex.
>98% depletion efficiency
Consistent, high-selectivity rRNA removal with low-bias libraries.
Bead-free & enzyme-free
No magnetic rack, no RNase H or DNase digestion required.
Ready to run
Pre-configured catcher strands included. Add your total RNA and run the protocol.
Less than half the price
Dramatically more affordable than magnetic-bead and enzymatic kits.
7× fewer off-target outliers
Than beads or enzymes, for cleaner downstream analysis.
Shelf-stable
Stable for approximately 1 year at 4°C. No dry-ice shipping.
Minimal hands-on time
Less than 5 minutes per sample, under 15 minutes for a full 24-sample run.
Tested in the following configurations.
Species & targets
Human
Validated
Human / mouse / rat
Underway
Pan-bacteria
Planned
Globin (blood)
Planned
Need something else? Contact us.
Discover the LASSO platform behind riboLASSO.
A bead-free, enzyme-free rRNA depletion workflow built on the LASSO platform. It removes abundant ribosomal RNA before RNA-seq library prep, so more of your reads go toward informative RNA.
Most established workflows rely on probe hybridization followed by RNase H or DNase digestion. riboLASSO uses programmable LASSO capture chemistry and does not depend on either enzyme during depletion.
No. It is bead-free. The capture material forms a pellet recovered by centrifugation, and the depleted RNA is recovered from the supernatant. No magnetic rack is needed.
Purified total RNA is the standard input. Crude lysates can also be used if sufficient nuclease inhibitors, such as EDTA, are present to protect the sample during the reaction.
Guides: rRNA depletion for RNA sequencing · rRNA removal methods compared · Ribo-Zero alternatives · rRNA depletion vs poly(A) selection
