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riboLASSO: cleanest rRNA depletion for RNA-seq

Bead-free, enzyme-free rRNA depletion. >98% depletion efficiency, at less than half the price of other depletion kits.

What is rRNA depletion?

riboLASSO at a glance

Reference DM-RLH-1. Pre-configured catcher strands included, add your total RNA and run.

riboLASSO rRNA depletion kit, reference DM-RLH-1

Ready-to-Use Kit

Compatible with
IlluminaOxford NanoporePacBio
Built for
RNA-seqWhole transcriptomeMetatranscriptomicsPoly-A alternative

Need a custom DNA or RNA target instead? Try LASSOflex.

What makes riboLASSO unique and powerful

>98% depletion efficiency

Consistent, high-selectivity rRNA removal with low-bias libraries.

Bead-free & enzyme-free

No magnetic rack, no RNase H or DNase digestion required.

Ready to run

Pre-configured catcher strands included. Add your total RNA and run the protocol.

Less than half the price

Dramatically more affordable than magnetic-bead and enzymatic kits.

7× fewer off-target outliers

Than beads or enzymes, for cleaner downstream analysis.

Shelf-stable

Stable for approximately 1 year at 4°C. No dry-ice shipping.

Validated across sample types and formats

Tested in the following configurations.

Species & targets

Human

Human

Validated

Human Mouse Rat

Human / mouse / rat

Underway

Bacteria

Pan-bacteria

Planned

Globin (blood)

Planned

Need something else? Contact us.

The science behind the selection

Discover the LASSO platform behind riboLASSO.

Explore LASSO technology →

Let's talk about your RNA workflow

Discuss your samples