Validated with human MSCs, iPSCs, trophoblast organoids, breast cancer tumoroids, glioblastoma and MDCK kidney cysts. There are many more cell types which are currently in validation (brain organoids, gastrointestinal organoids, fibroblasts, heart)
The pilot programme is the fastest way to test your cell system.
As aqueous solutions, DyNAtrix is stable at 4°C for more than 6 months. No dry-ice shipping required.
Yes. Optically transparent and compatible with confocal, fluorescence, and light-sheet microscopy. Fix and stain inside the gel, with no need to remove cells first.
Add DNase I to culture medium at 37°C for around 30 minutes. The gel dissolves gently, releasing cells and organoids with high viability, ready for sequencing, flow cytometry, or passaging.
No. Fully synthetic and growth factor-free. You add only what your experiment requires, with no background signalling from undefined endogenous factors
In Minimal Discovery kit, stiffness can be adjusted from 1-100 Pa, and Stress-relaxation can be explored between two timescales. Please contact us if you would like advanced kits (Stiffness: 1-400 Pa, Stress-relaxation: <1s - >100,000s).
DyNAtrix is a fully synthetic, animal-free alternative to Matrigel and other basement membrane extracts. Because its composition is chemically defined, it removes the batch-to-batch variability and undefined growth factors that come with tumour-derived matrices.
Yes. DyNAtrix contains no animal- or human-derived components. It aligns with New Approach Methodologies (NAMs) and animal-free research initiatives.
DyNAtrix is a synthetic polymer network held together by DNA crosslinkers. The mechanical behaviour of the gel is set by the crosslinker formulation, with no animal-derived proteins involved. There are adhesion peptides to help with cell adhesion.
Because the matrix actively shapes how your cells behave. A defined, consistent composition means your results reflect your experimental variable rather than lot-to-lot differences in the scaffold, which is essential for reproducibility, drug screening, and translational work.
The precursors are liquid when cold, so you mix them with your cell suspension on ice, then transfer to 37°C. Gelation completes over about 60 minutes. The workflow is comparable to handling a basement membrane matrix.
Yes. The handling steps are designed to mirror a typical Matrigel workflow, so most labs adapt their existing protocols with little change.
DyNAtrix works in standard labware, including multi-well plates, microfluidic chips, and cell culture inserts.
Yes. It supports extended 3D culture over days to weeks while maintaining viability and morphology. We have tested cell culture upto 60 days in serum-free media.
Yes. It is shear-thinning and self-healing, which makes it suitable for extrusion-based bioprinting, and it retains its mechanical properties after printing. Contact us for bioprinting-specific protocols.
Yes. DyNAtrix is permeable and low-fouling, so you can perform antibody staining in the gel without removing cells first.
DyNAtrix is currently available at 2 ml scale. One could make multiple orders. For larger volume, please contact us at contact@dynamicmatrices.eu.
DyNAtrix works in serum-free and chemically-defined media.